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Research Papers

Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review (2022) Ko, K., Knight, G., Rucker, J.J., Cleare, A.J.

 A meta-analysis that looked at 12 studies of psychedelic therapy using psilocybin, ayahuasca, or ketamine.  They were all studies to test the effects of psychedelic-assisted therapy on certain afflictions, including treatment-resistant depression, MDD, cancer-related stress, tobacco addiction, alcoholism, and cocaine dependence. 

Psychedelics Alter Metaphysical Beliefs (2021) Timmerman, C., Kettner, H., Letheby, C., Roseman, L., Rosas, F.E., & Carhart-Harris, R.L.  Nature 
A survey study performed on 866 volunteers who were planning on attending a psychedelic retreat, ceremony, or guided journey.  The participants filled out online questionnaires about their metaphysical beliefs before their psychedelic use, and at timepoints afterward.  The survey was also given to individuals in a psilocybin trial at Imperial College in London.   FINDINGS: In general, participant metaphysical views shifted from a materialist, or naturalistic, view of the world (physical matter and energy and the known laws of physics are the only factors affecting our reality) to a dualist, fatalist, or panpsychist view.


5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics (2022) Schmitz, G.P., Jain, M.K., Slocum, S.T., Roth, B.L.  ACS Chem Neurosci 
Research on different 5-HT2A serotonin receptors resulting from genetic diversity present in the human population.  Found that these receptors can interact differently with psychedelics, including 5-MeO-DMT, LSD, psilocin and mescaline, compared with normal (wild-type) 5-HT2A receptors. 

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